AMPK is an enzyme naturally found in all mammalian cells, including human cells. It acts as a ‘spark plug’, igniting fat and providing fuel in the form of glucose, the body’s preferred source of energy. It is activated during times of metabolic stress, specifically stress that causes glucose or oxygen deprivation (hypoxia) such as intense exercise.
During intense exercise (either at an intensity above roughly 60% of maximum aerobic capacity or at a lower intensity for very prolonged periods), AMPK is activated, or ‘switched on’, in the skeletal muscle, body fat (adipose tissue) and liver. When activated, AMPK serves to stimulate glucose uptake within the muscles and adipose tissue, therefore reducing the level of glucose available for absorption into the bloodstream. It also increases the fat burning capabilities of the muscles and the liver. Combined, these mechanisms support the increased generation of energy and burning of fat.
Activated AMPK also temporarily reduces the rate of high energy consuming processes such as the synthesis of lipids and proteins. The collective actions of AMPK allow for more energy available to the muscles, which is needed during prolonged or high-intensity exercise.
The Role of InnoSlim® Supplementation and AMPK Activation
InnoSlim® is a proprietary blend of compounds extracted from Panax notoginseng and Astragalus membranaceus. It is an entirely natural supplement derived from plants and may help support safe and sustainable weight and blood glucose management.*
InnoSlim® assists weight loss by reducing calorie intake and increasing calorie expenditure by supporting the following actions:
It does this, in part, by further activating the AMPK present in skeletal muscle and fat cells, in a similar manner to the way exercise does.
The Science Behind InnoSlim® Supplements and AMPK Activation
NuLiv Science has completed in-vitro, in-vivo and human studies on InnoSlim®. These studies have demonstrated its ability to boost AMPK expression in muscle cells by a minimum of 50% and in fat cells by a minimum of 300%.
One study involved adding InnoSlim® to an in-vitro solution of human muscle cells at increasing concentrations and measuring the resulting activity of AMPK. It showed that increasing levels of InnoSlim® from 0.001 μg/mL to 1.0 μg/mL increased phospho-AMPK expression from 152 percent to 271 percent of the original level before the introduction of InnoSlim®.
What is Phospho-AMPK?
Phospho-AMPK is phosphorylated AMPK. Phosphorylation involves the attachment of a phosphoryl group to a molecule, for example, to a molecule of AMPK. Along with dephosphorylation, the removal of a phosphoryl group from a molecule, it is an essential process for the regulation of the crucial functions of enzymes, such as AMPK.
The increased level of the phosphorylation of AMPK detected by our laboratory assays on InnoSlim® and muscle cells suggests an increased activity of AMPK as the concentration of InnoSlim® was increased.
In a similar study, this time on an in-vitro solution of human fat cells, increasing InnoSlim® concentrations from 0.001 μg/mL to 1.0 μg/ml increased phospho-AMPK expression from 300 percent to 400 percent of the original level before the introduction of InnoSlim®.
Increased phospho-AMPK expression in both skeletal cells and fat cells suggests an increase in fat burning and glucose-regulating ability and therefore, healthy and sustained weight loss.
Stimulant-Free Weight & Blood Glucose Management with InnoSlim®
Given its ability to help support the role of AMPK in reducing glucose absorption into the bloodstream and increasing the level of glucose available to the muscles and liver, InnoSlim® also has benefits for the management of type 2 diabetes and other metabolic disorders.
The fat burning and glucose metabolism benefits of AMPK activation naturally decreases with age. InnoSlim® is a safe and highly researched supplement that can help reverse this trend, enhance the enzymatic activity of AMPK and improve the body’s fat utilization when taken long-term as part of a healthy diet and lifestyle.
Taken at a dose of 250mg per day, we envisage InnoSlim® in continuing to be an important aspect of sports nutrition to help support healthy body fat composition and the normalizing of metabolism pathways.