Weight management , Wellness ,

Challenging Insulin Resistance & Supporting Metabolic Efficiency with InnoSlim®

Jan 25 , 2021 - Josh Beaty
Challenging Insulin Resistance & Supporting Metabolic Efficiency with InnoSlim®

It’s easy, simplistic even, to think of weight loss only as a case of eating less and moving more. This is essentially true. To lose weight, we must consume fewer calories and burn more calories through increased activity and exercise. But it isn’t quite as straightforward as that if we’re serious about looking and feeling our best and making the most of our training efforts.

To really understand the mechanics behind weight loss, we must consider our metabolic efficiency. And more specifically, our insulin sensitivity. Both can have a profound impact on how we manage our weight.

That said, here is the true science behind weight loss and how it relates to metabolism and insulin. Plus, how we can help your customers support healthy weight management and a strong metabolism.

What is insulin sensitivity?

First up, let’s explore insulin. Insulin is a hormone that has a major part to play in how well our blood glucose (sugar) levels are regulated. When we eat a sugary meal (or carbohydrates, which are broken down into their constituent parts – sugars), our blood glucose levels rise.

This reaction triggers the release of insulin from the pancreas which signals to the cells of the liver and muscles to take in glucose from the blood. Glucose is then stored and is used for energy. If the body has enough energy, the excess glucose is stored as glycogen, from where it can be turned back to glucose when the body needs more energy.

As well as regulating blood glucose levels, insulin also plays a role in how our body uses and stores fat. If the liver is storing its full capacity of glycogen, the fat cells are then instructed to take up glucose, where it’s stored as triglycerides. Hence why eating a high sugar diet leads to a gain in fat stores and weight – the glucose has no use within the body and is instead stored as fat.

Insulin sensitivity describes how well our body responds to insulin. If we have a high sensitivity to insulin, we only need small amounts of insulin to manage blood sugar levels and keep them in a lower healthy state.

If we have a low sensitivity to insulin, we require more insulin to keep our blood sugar levels low. Low insulin sensitivity is also known as insulin resistance.

The challenge of insulin resistance

Insulin resistance means that we require higher levels of insulin to deal with heightened blood glucose levels. Although, having higher insulin levels in our blood can damage the blood vessels. As such, insulin resistance is often seen in conjunction with heart disease, high blood pressure, high cholesterol, and obesity (but not always).

Insulin resistance manifests itself in a variety of symptoms. These include tiredness, brain fog, hunger, and weight gain, particularly around the midriff. It could also be a precursor to prediabetes, metabolic syndrome, and eventually, type 2 diabetes.

Having high levels of insulin circulating in the blood doesn’t necessarily mean that we’ll have lower blood sugar levels either. Often, even with excess insulin, glucose levels remain high. So then we are left with the doubly problematic issue of high blood glucose and high insulin levels. This then leads to excess fat storage within the liver and the fat cells, once again leading to weight gain.

Metabolic efficiency and metabolic syndrome

Eating a diet high in sugar, carbohydrates, fat, and calories, coupled with relative inactivity, leads to weight gain. It can also lead to insulin resistance and metabolic syndrome. Metabolic syndrome is when an individual is overweight or obese, has high blood pressure, and has prediabetes or type 2 diabetes. A trio of health conditions that can be extremely dangerous.

Metabolic efficiency is how well we burn fat both during exercise and at rest. Someone with metabolic syndrome or who is overweight or obese can also struggle to break down body fat. This is considered poor metabolic efficiency and is thought to be due to low levels of adiponectin.

Adiponectin is a hormone in the body that’s responsible for activating an enzyme called Adenosine Monophosphate Activated Protein Kinase, or AMPK, amongst others. AMPK is a ‘spark plug’ for our cells. It helps to regulate the breakdown of glucose and fat within the blood, fat cells, muscles, and liver.

Having low levels of adiponectin is linked to having insulin resistance and high levels of fat in the blood. It can therefore mean that we are caught in a vicious cycle of being overweight or obese, and this is making it biologically difficult for us to lose weight and get into a healthier state.

How InnoSlim® could make a difference

InnoSlim® is NuLiv Science’s proprietary nutraceutical that helps to manage weight loss and support metabolic efficiency. Developed using purified extractions from Panax notoginseng and Astragalus membranaceus, it consistently demonstrates the ability to regulate glucose and fat metabolism by addressing the problems of insulin resistance and poor metabolic efficiency.

The science is clear – the body stores excess glucose as fat. Excess glucose, over time, leads to an increase in fat, weight gain, and insulin resistance.

InnoSlim® helps to combat these problems in the following ways:

  • Decreasing the absorption of glucose in the intestine
  • Reducing the activity of sodium-glucose cotransporter 1 (SGLT1), which transports glucose into the gut for absorption
  • Increasing the absorption of glucose by the muscle and fat cells
  • Increasing the activity of glucose transporter type 4 (GLUT4), which is found in the adipose tissue which stores energy in the form of fat
  • Decreasing the formation of fatty acids and inflammation within the fat cells

Collectively, these factors all help to reduce the level of glucose circulating in the blood. In turn, this helps to reduce fat accumulation.

InnoSlim® also has the ability to reduce inflammatory biomarkers that are associated with a higher risk of insulin resistance and metabolic syndrome. Hence helping to combat the vicious cycle of weight gain making weight loss difficult for many people.

Research shows that InnoSlim® favors the breakdown of fatty acids. This then helps to balance the homeostasis of fatty acid and glucose metabolic efficiency. The benefit of this is better weight management and a reduced risk of metabolic disorders.

In fact, 18 in-vitro, two in-vivo, and one human clinical study published in the Journal of Agricultural and Food Chemistry, Molecular Pharmacology, and Adoptive Medicine back this up.

These studies show that InnoSlim® works to reduce blood glucose, triglycerides, and body fat levels. It also may decrease the chance of insulin resistance and inflammation. This can lead to weight loss and a reduction in blood sugar and insulin levels. InnoSlim® also impacts hunger levels, increasing the time it takes to reach satiety.

We live in a world where obesity, insulin resistance, and metabolic syndrome are on the rise. Never before has it been so important to tackle this health crisis. And never before have your customers and potential customers been so aware of their health.

Adding InnoSlim® to your nutraceutical formula could be the best thing you do this year. Contact us to discover how we can help you give your customers exactly what they are looking for.

References

https://www.diabetes.co.uk/insulin/insulin-sensitivity.html
https://www.diabetes.co.uk/insulin-resistance.html
https://www.medicalnewstoday.com/articles/325328
https://pubmed.ncbi.nlm.nih.gov/20205102/
https://pubmed.ncbi.nlm.nih.gov/15619075/
https://pubmed.ncbi.nlm.nih.gov/25390017/