Zylaria® supports sleep and mood by working to support GABA levels within the brain
ZYLARIA® MECHANISM OF ACTION
HEALTH BENEFITS
- Supports Elevated Mood*
- Promotes Relaxation & Deeper Sleep*
- Supports Better Sleep Quality*
- *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. The information presented here is intended for business-to-business (B2B) purposes only and should not be considered as medical advice or claims for end-users. Always consult with a qualified healthcare professional before starting any new supplement or health program.
ZYLARIA® SUPPORTS GABA
AND HEALTHY BRAIN FUNCTIONS
Cell Viability (%)
GABA Contents
(ng/mg protein)
GABA T Activity
(nmols/h/mg protein)
GAD Activity
(mU/mg of protein)
HOW ZYLARIA® WORKS
As night approaches, the body and mind should naturally begin to relax and signal that it’s time for sleep. Unfortunately, for many people, this process does not occur due to various factors. One essential amino acid the body requires for this process is called Gamma-Aminobutyric acid (GABA) which allows the brain to communicate these important messages throughout the body.
GABA acts as a neurotransmitter in the brain, promoting relaxation.1 GABA-T breaks down GABA into SSA and glutamate. Glutamate plays a role in starting and keeping our sleep/wake cycles in balance.2 GAD (glutamic acid decarboxylase) is an enzyme that plays a critical role in the balance of neurotransmitters in the brain, specifically GABA. By converting glutamate to GABA, GAD helps to keep the balance of neurotransmitters in the brain in check, which is important for maintaining normal brain function, including sleep/wake cycles.
Adenosine has long been known to induce sleep via adenosine receptors.3 Finally, genistein supports the expression of brain-derived neurotrophic factor (BDNF) mRNA and protein levels.4 Several studies show that low levels of BDNF in the brain could be related to lower mood and inadequate sleep quality.5
NuLiv Science preclinical studies on Zylaria® demonstrated elevated GABA content in brain cells by increasing GABA content and GAD activity. Zylaria® also demonstrated in a human trial to support the sleep quality and mood of tested subjects.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. The information presented here is intended for business-to-business (B2B) purposes only and should not be considered as medical advice or claims for end-users. Always consult with a qualified healthcare professional before starting any new supplement or health program.
SLEEP SUPPORTING FORMULAS
Sleep Supplements, recovery formulas, and relaxation focused products
FUNCTIONAL FOOD & BEVERAGES
Powdered drink mixes, teas, adaptogenic snacks, and gummies
NUTRACEUTICALS
Vitamins and Minerals, mood support, cognitive support, etc.
100% Plant Based
Gluten-Free
ETO Free
Halal
Highly purified fractions extracted from Xylaria nigripes extract (mycelium), Cuscuta
chinensis (seed) extract, and Panax notoginseng (root) extract.
Clinical Dosage: 500mg
- SF Huang, etc. Effect of Xylaria nigripes, Panax notoginseng, Cuscuta chinensis on GABA, GABA transaminase, Glutamate decarboxylase, Amyloid beta, and Amyloid beta aggregation levels in PC12 neuron cells. J Biochem Biotech 2022 Volume 5 issue 5
- Lenin D. Ochoa-de la Paz, Rosario Gulias-Cañizo, Estela D´AbrilRuíz-Leyja. et al. The role of GABA neurotransmitter in the human central nervous system, physiology, and pathophysiology. Revistamexicana de neurociencia. 2021, 22(2), p. 67-76.
- Shi Yu-Feng, Yu Yan-Qin. The roles of glutamate in sleep and wakefulness. Journal of Zhejiang University.2013, 42(5), p. 583-590.
- Theresa E. Bjorness and Robert W. Greene. Adenosine and Sleep. Current Neuropharmacology. 2009, 7(3), p. 238–245.
- M. Pan, H. Han, C. Zhong,Q. Geng. Effects of genistein and daidzein on hippocampus neuronal cell proliferation and BDNF expression in H19-7 neural cell line. J Nutr Health Aging. 2012, 16(4), p. 389-394.
- Barbara C. Monteiro, Suzana Monteiro, Maristela Candida, et al. Relationship Between Brain-Derived Neurotrofic Factor (Bdnf) and Sleep on Depression: A Critical Review. Clin Pract Epidemiol Ment Health. 2017, 13, p. 213–219.
- HeXin-rong, Liu Pin. Determination of 14 kinds of amino acids in Wuling Capsule by HPLC-FLD. Chinese Traditional Patent Medicine. 2010, 32(8), p. 1358-1361
- M. Pan, H. Han, C. Zhong,Q. Geng. Effects of genistein and daidzein on hippocampus neuronal cell proliferation and BDNF expression in H19-7 neural cell line. J Nutr Health Aging. 2012, 16(4), p. 389-394.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.