Muscle, like all tissue, is made of a network of cells. These cells are constantly dividing and regenerating to maintain the health and function of the tissue as they age. Although at a certain point, the cells may stop regenerating and become senescent; meaning, the cell stops multiplying but doesn’t die off when it should.

The higher density of senescent cells in a tissue, the lower the tissue can perform. In a perfect world, senescent cells are recognized and cleared by phagocytes, a type of immune cell within the body that engulfs and clears away unwanted items including bacteria, pathogens, and dead cells.²

Taking Senactiv^® before physical activities or exercise activates macrophages for rapid senescent cell clearance, allowing migration of stem cells into exercised muscle for new muscle cell generation. Our scientists made the discovery that the aging cells accumulated in the muscle are mostly stem cells which are responsible for the regeneration of muscle and blood vessels.

Younger muscle cells work longer, harder, and recover faster than older muscle cells because they have higher mitochondria counts which produce energy, greater ATP energy production capacity, and higher glycogen storing capacity. Senactiv^® is the first senolytic for enhanced exercise performance on the market.^{1, 2, 3, 4, 5, 6, 7, 8, 9}

Senactiv^® increases endurance by increasing glycogen and energy production in the muscle cells through lowered inflammation during exercise through increasing insulin sensitivity, reduced lipid peroxidation, and increased mitochondria density from rapid muscle regeneration as evidenced by our TBARS, MDA, TNF-α, IL-10, glycogen replenishment, and citrate synthase activity studies.

Senactiv^® speeds up muscle fatigue recovery by lowering muscle inflammation and accelerating muscle regeneration through senescent cell clearance for rapid new muscle cell regeneration as evidenced by our TBARS, MDA, IL-6, CK, TNF-α, IL-10, SA-gal, P16ink4α+ muscle cells, apoptotic nuclei, iNOS, Pax7, Mfy5, total glutathione, and centrally nucleated myofibers studies.^{1, 2, 3, 4, 5, 6, 7, 8, 9}

*These statements may not comply with your country’s laws and regulations or with Reg. EC n. 1924/2006 and have not been evaluated by the Food and Drug Administration. The products are not intended to diagnose, treat, cure or prevent any disease. Marketers of finished products containing this ingredient are responsible for ensuring compliance with the applicable legal framework.