AstraGin® is a patented, plant-based compound providing full-spectrum gut support through enhanced absorption, microbiota and immune cell viability, and supporting a healthy intestinal wall environment
Mechanism of action
Enhances Absorption, restores gut wall integrity, promotes microbiota homeostasis, and activates the immune system
Scientific Statement on Mechanism of Action: AstraGin® enhances nutrient absorption by up-regulating nutrient transporters, such as CAT1, SGLT1, and FR. AstraGin® restores gut wall integrity by triggering an anti-inflammatory response and activating the mTOR pathway for rapid intestinal stem cell migration and differentiation in the inflamed intestinal mucosal barrier (epithelial cell and tight junction). AstraGin® promotes gut ecosystem homeostasis by the symbiotic effect of restoring gut wall integrity and increasing microbiota-immunity communication. Lastly, AstraGin® activates the immune system through the symbiotic effect of improved gut wall integrity and enhanced microbiota-immunity communication.
RESEARCH SUPPORTED HEALTH BENEFITS
- Enhanced nutrient absorption*
- Supports a healthy intestinal wall environment at the cellular level*
- Strengthens gut-based immune system*
- Supports microbiota population in the gut*
ASTRAGIN® ENHANCES AMINO ACIDS, FATTY ACIDS, VITAMIN, AND PHYTONUTRIENT ABSORPTION
Absorption of Amino Acids (%)
Absorption of Fatty Acids (%)
Absorption of Folate (%)
Absorption of Phytocompound (%)
Three-Months Percent Changes (%)
Percent Changes (%)
HOW ASTRAGIN® WORKS
A healthy gut is key to a healthy body and mind. The gut is home to 70% of the body’s immune system, and has a large impact on much of the body’s essential functions. Before entering circulation to be utilized by the body, consumed nutrients must first be absorbed through the gut. Although some nutrients and nutraceuticals are often poorly absorbed because of their poor water solubility, larger molecular size, structure instability, and other factors.
In the health and wellness industry companies have worked to overcome these barriers with a variety of approaches. Some absorption-enhancing nutraceuticals encapsulate nutrients that do not mix well with water into microscopic fat-soluble vesicles to solve the absorption problem which can be costly to implement.
Others achieve a higher concentration of nutrients in the body by suppressing specific metabolic enzyme complexes, delaying the transport time and metabolism of the nutrient. We believe specific botanicals in the optimal format, such as AstraGin®, can both address the challenge with cost-drivers and innovation in product formulas.
AstraGin® enhances absorption by increasing nutrient transporters within the gut through; such as
• CAT1 for arginine, lysine, and histidine absorption
• SGLT1 for glucose absorption
• FR for folate absorption
Unlike other absorption methods, AstraGin® works with the body’s normal functions to support the way amino acids, fatty acids, vitamins & minerals are naturally absorbed within the body.
Another limiting factor to nutrient absorption is inflammation of the gut. Chronic inflammation in the intestines, characterized by damage and inflammation of the mucosal barrier, affects the absorption of nutrients, the population of microbiota, and immune functions. AstraGin® promotes a healthy intestinal mucosal barrier by triggering an anti-inflammatory response and activating the mTOR pathway for rapid intestinal stem cell migration and differentiation in the inflamed area.
NuLiv Science in-vivo and clinical trials have shown a reversal of intestinal mucosal damage and inflammation when AstraGin® was administered. These same studies showed an indication of a positive microbiota environment when AstraGin® was administered as well as evidence of immune support; suggesting AstraGin® may support and promote a healthier gut barrier, microbiota population, and immune capability.*
The mucosal lining of the gastrointestinal tract is central to nutrient uptake and acts as a barrier against bacteria and toxins. Taking AstraGin® on a regular basis supports the body’s natural ability to absorb more nutrients, limit toxins from entering the body, provide a favorable eco-environment for microbiota, and support immune cell population and vitality. 1, 2, 3, 4
US8197860 B2, US 13/444765, US 13/444770, US 12/424193 US 12/345218
CN 200610090113.0, CN 200610090114.5, CN 200910178493.7, CN 200910178492.2
TW I271195, TW I317280
Highly purified fractions extracted from Astragalus membranaceus and Panax
notoginseng standardized to 1.5% total saponins.
Clinical Dosage: 50mg
100mg per day for targeted gut health therapeutic product formulation.
- TC Chang, et. Effect of Ginsenosides on Glucose Uptake in Human Caco-2 Cells Is Mediated through Altered Na Glucose Cotransporter 1 Expression. J. Agric. Food Chem. 2007, 55, 1993-1998.
- SF Huang, etc. Effect of Ginsenoside Rb1 on Glucose Uptake and Expression of Glucose Transporter in Animal Cells. Institute of Cardiovascular Sciences, University of Manitoba, Canada. April 2010.
- SY Lee, etc. Astragaloside II promotes intestinal epithelial repair by enhancing L-arginine uptake and activating the mTOR pathway. Scientific reports. September 2017.
- WL Chang, etc. Astragalus membranaceus and Panax notoginseng saponins improves intestinal arginine absorption and protects against intestinal disorder in vivo. Food sciences and research technology. Journal of Food Science and Technology Research, Dec. 2022.
- NuLiv Science AstraGin GRAS Final Report with Signatures.
*These statements may not comply with your country’s laws and regulations or with Reg. EC n. 1924/2006 and have not been evaluated by the Food and Drug Administration. The products are not intended to diagnose, treat, cure or prevent any disease. Marketers of finished products containing this ingredient are responsible for ensuring compliance with the applicable legal framework.