Astrion® is a patented and clinically-studied plant-based ingredient to enhance skin’s firmness, smoothness, and hydration through the internal production of collagen and hyaluronic acid
MECHANISM OF ACTION
SKIN HEALTH BENEFITS
- Increase in collagen and hyaluronic acid levels in skin cells*
- Increase in glucosamine and proline absorption in skin cells*
- Reduction in MMP gene expression in skin cells*
- Reduction in the appearance of wrinkles and age spots in human study*
ASTRION® INCREASES COLLAGEN AND HYALURONIC ACID IN HUMAN SKIN CELLS
Proline Uptake (%)
Collagen Levels (%)
Collagen Breakdown (%)
Hyaluronic Acid Synthesis (%)
Human Trial (%)
HOW ASTRION® WORKS
Astrion® increases skin cells’ ability to produce more pro-collagen and hyaluronic acid as well as reduces collagen breakdown in the cells. Studies in cultured cells demonstrated that Astrion® increased skin cells’ ability to produce 80% more collagen and 20% more hyaluronic acid, improved proline and glucosamine absorption in dermal cells by 27% and 11%, and inhibited MMPs (an enzyme that breaks down collagen and elastin in the connective tissues between the skin cells) production and collagen breakdown by 51% when compared to the control group. In a human study, Astrion® demonstrated reduced wrinkles and melanin by 15% and 17% in 30 days.1, 2, 3, 4, 5
US Patent No. 7,959,952; TW Patent No. I362936; CN Patent No. 200710089586.3.
Highly purified fractions extracted from Astragalus membranaceus (root) and
Centella asiatica (whole plant)
250mg – Oral Solutions
5% – Topical Solutions
1. WL Chang, etc. The rejuvenating effects of astragalus membranaceus and centella asiatica saponins on human skin. J Biochem Biotech. Volume 4 issue 4, 2021.
2. Hong M.J. et al. Inhibitory effect of Astragalus membranaceus root on matrix
3. metalloproteinase-1 collagenase expression and procollagen destruction in ultraviolet B-irradiated human dermal fibroblasts by suppressing nuclear factor kappa-B activity. J Pharm Pharmacol. 2013; 65(1):142-8.
4. B Chen, etc. Astragaloside IV controls collagen reduction in photoaging skin. Molecular medicine reports 11: 3344-3348, 2015.
5. Lee J et al. Asiaticoside induces human collagen I synthesis through TGFbeta receptor I kinase (TbetaRI kinase)- independent Smad signaling. Planta Med 2006; 72: 324-328.
6. A Shukla, etc. In vitro and in vivo wound healing activity of asiaticoside isolated from Centella asiatica. Journal of Ethnopharmacology 65 (1999) 1–11.
*These statements may not comply with your country’s laws and regulations or with Reg. EC n. 1924/2006 and have not been evaluated by the Food and Drug Administration. The products are not intended to diagnose, treat, cure or prevent any disease. Marketers of finished products containing this ingredient are responsible for ensuring compliance with the applicable legal framework.