Zylaria® aims to support sleep and mood by potentially promoting GABA levels within the brain and encouraging cognitive functions through possible increased neuron cell viability and reduced amyloid beta aggregation*
ZYLARIA® MECHANISM OF ACTION
HEALTH BENEFITS
- Elevates Mood*
- Promotes Relaxation & Deeper Sleep*
- Supports Better Sleep Quality*
- Supports Healthy Brain Functions*
- *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. The information presented here is intended for business-to-business (B2B) purposes only and should not be considered as medical advice or claims for end-users. Always consult with a qualified healthcare professional before starting any new supplement or health program.
ZYLARIA® SUPPORTS GABA AND REDUCES
AMYLOID BETA IN NEURON CELLS
STUDY HIGHLIGHTS
Inhibition of Amyloid-Beta
Aggregation (%)
Cell Viability (%)
GABA Contents
(ng/mg protein)
GABA T Activity
(nmols/h/mg protein)
GAD Activity
(mU/mg of protein)
HOW ZYLARIA® WORKS
As nightfall approaches, the body and mind should naturally begin to relax and signal that it’s time for sleep. Unfortunately, for many people, this process does not occur due to various factors. One essential amino acid the body requires for this process is called Gamma-Aminobutyric acid (GABA) which allows the brain to communicate these important messages throughout the body.
GABA acts as a neurotransmitter in the brain, promoting relaxation in the central nervous system.1 GABA-T breaks down GABA into SSA and glutamate. Glutamate plays a role in starting and keeping our sleep/wake cycles in balance.2 GAD (glutamic acid decarboxylase) is an enzyme that plays a critical role in regulating the balance of neurotransmitters in the brain, specifically GABA. By converting glutamate to GABA, GAD helps to keep the balance of neurotransmitters in the brain in check, which is important for maintaining normal brain function, including sleep/wake cycles.
Adenosine has long been known to induce sleep via adenosine receptors.3 Finally, genistein increases the expression of brain-derived neurotrophic factor (BDNF) mRNA and protein levels.4 Several studies show that depressive subjects have low levels of BDNF in the brain. Poor sleep quality is also related to alterations in BDNF concentration.5
Six NuLiv Science in vitro studies on Zylaria® demonstrate elevated GABA content in PC-12 neuron cells by increasing GABA content and GAD activity as well as decreasing GABA-T activity in cells. Zylaria® also works to increase cell viability and decrease Aβ aggregation in tested cells.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. The information presented here is intended for business-to-business (B2B) purposes only and should not be considered as medical advice or claims for end-users. Always consult with a qualified healthcare professional before starting any new supplement or health program.
SLEEP SUPPORTING FORMULAS
Sleep Supplements, recovery formulas, and relaxation focused products
FUNCTIONAL FOOD & BEVERAGES
Powdered drink mixes, teas, adaptogenic snacks, and gummies
NUTRACEUTICALS
Vitamins and Minerals, mood support, cognitive support, etc.
Highly purified fractions extracted from Xylaria nigripes extract (mycelium), Cuscuta
chinensis (seed) extract, and Panax notoginseng (root) extract.
Clinical Dosage: 500mg
- SF Huang, etc. Effect of Xylaria nigripes, Panax notoginseng, Cuscuta chinensis on GABA, GABA transaminase, Glutamate decarboxylase, Amyloid beta, and Amyloid beta aggregation levels in PC12 neuron cells. J Biochem Biotech 2022 Volume 5 issue 5
- Lenin D. Ochoa-de la Paz, Rosario Gulias-Cañizo, Estela D´AbrilRuíz-Leyja. et al. The role of GABA neurotransmitter in the human central nervous system, physiology, and pathophysiology. Revistamexicana de neurociencia. 2021, 22(2), p. 67-76.
- Shi Yu-Feng, Yu Yan-Qin. The roles of glutamate in sleep and wakefulness. Journal of Zhejiang University.2013, 42(5), p. 583-590.
- Theresa E. Bjorness and Robert W. Greene. Adenosine and Sleep. Current Neuropharmacology. 2009, 7(3), p. 238–245.
- M. Pan, H. Han, C. Zhong,Q. Geng. Effects of genistein and daidzein on hippocampus neuronal cell proliferation and BDNF expression in H19-7 neural cell line. J Nutr Health Aging. 2012, 16(4), p. 389-394.
- Barbara C. Monteiro, Suzana Monteiro, Maristela Candida, et al. Relationship Between Brain-Derived Neurotrofic Factor (Bdnf) and Sleep on Depression: A Critical Review. Clin Pract Epidemiol Ment Health. 2017, 13, p. 213–219.
- HeXin-rong, Liu Pin. Determination of 14 kinds of amino acids in Wuling Capsule by HPLC-FLD. Chinese Traditional Patent Medicine. 2010, 32(8), p. 1358-1361
- M. Pan, H. Han, C. Zhong,Q. Geng. Effects of genistein and daidzein on hippocampus neuronal cell proliferation and BDNF expression in H19-7 neural cell line. J Nutr Health Aging. 2012, 16(4), p. 389-394.
GLUTEN-FREE
VEGAN
ETO FREE
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. These statements may not comply with your country’s laws and regulations or with Reg. EC n. 1924/2006. The information presented here is intended for business-to-business (B2B) purposes only and should not be considered as medical advice or claims for end-users. Always consult with a qualified healthcare professional before starting any new supplement or health program.