Skin rejuvenation and hydration through enhanced endogenous production of collagen & hyaluronic acid

Water soluble for topical and oral applications

12 in-vitro and 1 human clinical trial


  • US 7,959,952
  • TW I362936
  • CN 2007 10095863

Pennies per serving


Astrion is NuLiv Science's clinically-studied cosmeceutical composed of highly purified and fractionated extracts from Astragalus membranaceous and Centella asiatica produced by a proprietary extraction method. 

Astrion reduces the number and appearance of fine lines and wrinkles through increased endogenous production of collagen and hyaluronic acid as well as increased production of proline and glucosamine (the building blocks of collagen and hyaluronic acid, respectively) in skins cells, Astrion also reduces the breakdown of collagen in skin cells and skin discoloration due to UV light damage from the sun.

Specifically, Astrion has shown in 12 in-vitro and one human study to: 

  • Increase collagen I synthesis in epidermal cells (HaCaT cell) by 60%
  • Increase collagen I synthesis in dermal cells (HDF cell) by 80%
  • Increase collagen I secretion in dermal cells (HDF cell) by 45%
  • Increase collagen III synthesis in dermal cells (HDF cell) by 30%
  • Increase collagen III secretion in dermal cells (HDF cell) by 80%
  • Increase hyaluronic acid synthesis in epidermal cells (HaCaT cell) by 20%
  • Increase the hyaluronic acid synthase (HA Synthase 2) gene expression in epidermal cells (HaCaT cell) by 30%
  • Increase proline uptake in epidermal cells (HaCaT cell) by 27%
  • Increase glucosamine uptake in epidermal cells (HaCaT cell) by 11%
  • Increase telomerase activity in epidermal cells (HaCaT cell) by 265%
  • Decrease MMP-1 protein synthesis in dermal cells (HDF cell) by 51%
  • Decrease MMP-1 gene expression in dermal cells (HDF cell) by 50%
  • Reduce wrinkles by 15% (human study)
  • Reduces melanin by 17% for lightening up the skin (human study)


Skin Hydration


Solubility: Soluble in water
Color: Off white
Odor: Characteristic
Taste: Slightly sweet
Appearance: Fine granular powder
pH: 6.5-7.5 (1g in 100mL water)
Shelf life: 36 months
Preservatives: None


Our skin is made up of three main layers that work together to perform the many functions of the skin. The epidermis is the outer layer that acts as a barrier and contains melanin giving skin its color. The dermis is located below the epidermis containing sweat glands, blood vessels, hair follicles, collagen, and elastin. The hypodermis or subcutaneous layer is the deepest, or inner layer of the skin. This inner layer contains fat and collagen cells and acts as insulation and protection to the body.

As we age, the pathways between these layers begin to decrease in function leading to some visible skin aging. These pathways are responsible for activities like water transfer, collagen production, and hyaluronic acid production. All of these are vital pathways to maintaining healthy skin.

Have you ever noticed how a pinch of a baby’s arm feels firm, plump, and soft; whereas an elderly individual's arm may be lacking in that plumpness? The difference is due to the amount a protein known as collagen. In terms of skin, collagen provides the strength, structure, and cushioning commonly associated with young healthy skin. Collagen is a very flexible elastic support, meaning you can pinch the skin, and when you let go it will return to where it was before. In comparison, if you were to pinch the skin of an elderly person, it may not return to its place right away, leaving a sort of fold in the skin momentarily.

This may occur because collagen naturally decreases as humans age because of a decrease in activated pathways. Therefore, elderly individuals naturally have less collagen than younger people.

The “plumpness” also comes from moisture. Dehydrated or dry skin tends to easily crack and line. The key molecule for skin hydration is hyaluronic acid (HA). HA is a naturally occurring substance within the body, and unlike the name suggests, it is very hydrating and helps the skin maintain water flow and elasticity. This is because HA has a unique ability to bind and retain water, greatly increasing the moisture content in the skin. The higher water content in the skin leads to more youthful, pliable, resilient, and overall radiant appearance.

Natural aging tends to lead to less water transfer within the layers of the skin, as well as less HA being produced. Proper hydration with a good amount of naturally present HA leads to healthier looking and feeling skin. For these reasons, many topical skincare products now contain collagen and hyaluronic acid -- although the skin’s own production still remains low.

A more beneficial method would be to stimulate the natural production of these two elements to fix the problem from within.

Astrion has been proven through several forms of studies to increase natural collagen and hyaluronic acid production within the skin through both topical and internal formulas. Astrion is made from specific extracts of Centella asiatica and Astragalus membranaceus. Both of these herbs have a long history of promoting skin health.

Using Astrion can both stimulate the production of HA and collagen through the activation of natural pathways, and limit the breakdown of already existing HA and collagen in the skin.

The ingredient additionally reduces skin discoloration from sun damage by reversing UV induced melanin production, commonly known as “sun spots” leading to a more even skin tone with less visible UV damage.

In sum, this leads to a fuller, stronger, more hydrated skin with a radiant skin appearance.

Astrion is an ideal cosmeceutical ingredient that can be included in all skin care products that claim to rejuvenate and hydrate skin and bring aged and damaged skin back to life.