What Age Do Wrinkles Start? The Science Behind Collagen, Hyaluronic Acid & Astrion® for Skin Health
If you’re wondering when wrinkles really start—or how to slow them down—you’re not alone. Dermatologists agree that signs of aging like fine lines, dryness, and loss of elasticity begin earlier than most people expect.
The good news? New research continues to unlock science-backed ways to support skin health from the inside out. NuLiv Science’s latest clinical trial on Astrion®, a proprietary blend of Astragalus membranaceus and Centella asiatica, reveals measurable improvements in skin hydration, brightness, elasticity, and collagen production—both orally and topically.
Let’s dive into what causes wrinkles, how ingredients like collagen and hyaluronic acid help, and what makes Astrion® a next-gen solution for skin health.
When Do Wrinkles Actually Start? Earlier Than You Think.
Research shows that collagen production starts to decline by the age of 25, continuing to decrease by about 1% each year. Combined with UV exposure, stress, pollution, and other lifestyle factors, visible signs of aging often begin in your late 20s or early 30s—even if they aren’t pronounced yet.
The skin becomes thinner, less elastic, and more prone to dehydration. Fine lines often begin at expression points like the forehead and around the eyes, later progressing into deeper wrinkles as collagen and elastin break down.
Early intervention is key, and that’s where collagen-supporting compounds like hyaluronic acid—and now Astrion®—come into play.
How Collagen & Hyaluronic Acid Help With Wrinkles
Collagen is the structural protein that keeps your skin firm, elastic, and resilient. Hyaluronic acid (HA), meanwhile, plays a critical role in moisture retention, binding up to 1,000 times its weight in water to keep skin plump and hydrated.
Together, these compounds:
✔ Improve elasticity
✔ Reduce the appearance of fine lines
✔ Strengthen the skin barrier
✔ Accelerate wound healing and cell turnover
As we age, the body’s ability to produce both decreases. Which is why science-backed supplementation is becoming a core part of skin health routines—especially with clinically studied ingredients like Astrion®.
What Is Astrion®? A Dual-Action, Plant-Based Skin Health Ingredient
Astrion® is NuLiv Science’s proprietary, plant-based skin care ingredient developed using Astragalus membranaceus and Centella asiatica extracts. Both herbs have deep roots in Traditional Chinese Medicine for promoting skin regeneration and healing.
What makes Astrion® unique is its dual-delivery action supporting skin health via both oral supplementation and topical application.
New Clinical Study: Astrion® Supports Collagen, Hydration & Texture
NuLiv Science recently conducted its largest human clinical trial to date, published in Cosmetics Journal. The randomized, double-blind, placebo-controlled study included 150 healthy adults over a 3-month period.
Key results from the study:
| Delivery | Skin Health Outcome | % Improvement |
|---|---|---|
| Oral + Topical | Moisture retention | +12.9% |
| Oral + Topical | Skin brightness | +4.2% |
| Oral + Topical | Elasticity | +9.0% |
| Oral + Topical | Collagen content | +13.7% |
| Oral + Topical | Melanin (dark spots) | -8.2% |
| Oral Only | Pore reduction | -10.5% |
| Oral Only | Collagen content | +13.2% |
| Oral Only | Skin texture | -18.5% |
Combined topical + oral use delivered the most significant results, but even oral administration alone showed improvements in skin clarity, collagen, and overall dermal quality.
How Astrion® Works: Mechanism of Action
Astrion® acts at the cellular level by:
✅ Increasing collagen and hyaluronic acid synthesis in both dermal and epidermal layers
✅ Enhancing skin elasticity and moisture retention
✅ Supporting decreased melanin and MMPs (enzymes that break down collagen due to UV damage)
✅ Helping improve absorption of hydroxyproline, a key amino acid in collagen structure
Unlike many skin ingredients that work only topically, Astrion® has demonstrated that internal supplementation could lead to skin benefits—something few ingredients on the market can claim.
What Products Contain Astrion®?
Astrion® is featured in a growing number of beauty-from-within and nutricosmetic products. You’ll find it in advanced skin formulas, collagen blends, and hydration-enhancing supplements designed to support skin health naturally.
You can explore finished products containing Astrion® by visiting NuLivScience.com or searching for brands that formulate with clinically validated ingredients.
Why Astrion® Is a Game-Changer for Skin Health Brands
“This is our largest human clinical study to date,” said Richard Wang, CEO of NuLiv Science.
“As a plant-based skin health compound, Astrion® helps brands differentiate their collagen and skin health positioning.”
In a crowded skincare market, Astrion® offers:
🔬 Clinically proven efficacy in both oral and topical formats
🌱 Plant-based origin for clean-label, holistic appeal
📈 Market differentiation for beauty-from-within and anti-aging formulas
Whether you’re a brand formulator or an ingredient buyer, Astrion® offers a high-efficacy, science-backed edge in today’s competitive skin health space.
Support Your Skin from the Inside Out
Wrinkles may start forming earlier than you expect—but that doesn’t mean you’re powerless. Supporting collagen and hydration through internal and topical strategies is now easier than ever with the emergence of clinically proven ingredients like Astrion®.
To learn more about the science and find out how to bring Astrion® into your next product formulation, visit:
👉 https://www.nulivscience.com