01

The Research Library.

Every study behind our ingredients. Human trials, mechanism work, and safety data across the portfolio.
02
Featured research

Effects of Astragalus membranaceus and Panax notoginseng Saponins Extract on the Pharmacokinetics of Whey Protein Absorption, Intestinal Permeability, and Muscle Function

This randomized, double-blind human study examined how AstraGin® influences whey protein absorption, intestinal barrier integrity, and muscle function across different age groups. Findings showed enhanced absorption of key amino acids — particularly leucine and valine — alongside improvements in grip strength, muscle mass, and intestinal barrier markers, with the most pronounced effects observed in older study participants.
Read the full paper
03
INGREDIENT
study type
SHOWING 1-9 OF 0 RESULTS
Sort by

Effects of Astragalus membranaceus and Panax notoginseng Saponins Extract on the Pharmacokinetics of Whey Protein Absorption, Intestinal Permeability, and Muscle Function

Post URL
This randomized, double-blind human study examined how AstraGin® influences whey protein absorption, intestinal barrier integrity, and muscle function across different age groups. Findings showed enhanced absorption of key amino acids — particularly leucine and valine — alongside improvements in grip strength, muscle mass, and intestinal barrier markers, with the most pronounced effects observed in older study participants.

Ginsenoside Rg1 enhances stem cell abundance in aging human skeletal muscle after resistance exercise

Post URL
This randomized, double-blind human study examined how Senactiv® ginsenoside Rg1 influences muscle stem cell activity and mitochondrial content following resistance exercise in women over 60. Findings showed that Rg1 supplementation significantly increased stem cell abundance, supported mitochondrial gains in muscle tissue, and helped maintain hormonal balance following exercise.

Saponins from Astragalus membranaceus and Panax notoginseng improve intestinal barrier function and probiotic adhesion in human intestinal Caco-2 cells

Post URL
This in vitro study examined how AstraGin® influences intestinal barrier integrity and probiotic adhesion under inflammatory conditions. Findings showed that AstraGin® helped preserve tight junction protein expression and barrier function, while also enhancing the growth and adhesion of Lactobacillus rhamnosus to intestinal cells.

Natural Plant-Based Rejuvenating Compositions: Human Studyon Astragalus membranaceus and Centella asiatica Saponins for Skin Health

Post URL
This randomized, double-blind human study examined how Astrion® influences key skin health markers when used topically, orally, or in combination across 150 participants over 12 weeks. Findings showed improvements in skin brightness, moisture, elasticity, collagen content, and pore appearance, with the greatest results observed in the combined treatment group.

Assessment of the Effect of Rehmannia glutinosa Leaf Extract in Maintaining Skin Health: A Proof-of-Concept, Double-Blind, Randomized, Placebo-Controlled Clinical Trial

Post URL
This randomized, double-blind human study examined how Verbasnol™ influences skin health markers in study participants over 56 days. Findings showed improvements in skin clarity, hydration, radiance, luminosity, smoothness, texture, and firmness, with no safety or tolerability concerns reported.

Astragalus and notoginseng extract: effects on arginine absorption, gut permeability, microbiome, immunity, and appetite

Post URL
This randomized, double-blind pilot study examined the effects of AstraGin® supplementation on arginine absorption, intestinal permeability, gut microbiota diversity, immune markers, and appetite in study participants over three months. Findings demonstrated improvements across all measured outcomes, including enhanced arginine absorption, improved intestinal integrity, increased beneficial bacteria populations, and favorable shifts in immune and appetite markers.

Astragalus and notoginseng saponins: arginine absorption and nitric oxide in healthy people

Post URL
This randomized, double-blind human study examined how AstraGin® influences arginine absorption and nitric oxide production in healthy participants. Findings showed that AstraGin® supplementation significantly increased arginine bioavailability and the arginine-to-ADMA ratio, with corresponding increases in urinary markers of nitric oxide production.

Astragalus and notoginseng saponins improve gut L-arginine absorption and support gut health in vivo

Post URL
This in vivo study examined how AstraGin® — derived from Astragalus membranaceus and Panax notoginseng — influences intestinal L-arginine absorption and supports intestinal health, with findings suggesting it may help protect against disruptions to normal intestinal function.

Astragalus saponins for joint cartilage support

Post URL
This in vitro study examined how Astragalus membranaceus saponins (AMS), the key component of JointIQ®, influence cartilage metabolism and degradation in human chondrocytes. Findings showed that AMS supported enhanced glucosamine uptake, hyaluronic acid production, and collagen II synthesis.

Cuscuta chinensis and Cnidium monnieri extracts for bone health

Post URL
This in vitro study evaluated a combination of Cuscuta chinensis and Cnidium monnieri extracts in human bone-forming cells across several extract ratios, with findings showing that the 3:1 and 1:1 combinations supported cell proliferation and increased markers associated with bone formation, including BMP-2, osteocalcin, type I collagen, alkaline phosphatase activity, and mineralization.

Astragalus and notoginseng extract: effects on glucose and lipid markers in humans

Post URL
This randomized, double-blind human study examined how InnoSlim® influences glucose and lipid markers in study participants over six weeks. Findings showed significant reductions in blood glucose and triglyceride levels, alongside improvements in HDL, adiponectin, and key metabolic signaling markers, with no adverse effects observed.

Xylaria nigripes, notoginseng, and Cuscuta chinensis: effects on GABA and related enzymes

Post URL
This in vitro study examined how Zylaria, a botanical blend of Xylaria nigripes, Panax notoginseng, and Cuscuta chinensis, influences GABA production and related enzyme activity in neuron cells. Findings showed that the full three-ingredient combination significantly increased GABA production and supported the activity of key enzymes involved in GABA synthesis.

Astragalus and Centella asiatica saponins: rejuvenating effects on human skin

Post URL
This in vitro and human study examined how Astrion® influences key skin health markers. Findings showed increased collagen and hyaluronic acid synthesis, enhanced absorption of skin-supporting nutrients, reduced appearance of wrinkles and melanin, and improved skin elasticity in study participants.

Astragalus and notoginseng saponins improve glucose and fat metabolism through adiponectin

Post URL
This in vitro, preclinical, and human study examined how InnoSlim® influences glucose and fat metabolism across multiple model systems. Findings showed improvements in key metabolic markers including adiponectin levels, glucose uptake, and lipid profiles in study participants, alongside supporting cellular signaling pathways involved in metabolic regulation.

Reduced stem cell aging in exercised human muscle with ginsenoside Rg1

Post URL
This randomized, double-blind human study examined how Senactiv® ginsenoside Rg1 influences muscle stem cell aging markers and inflammation following resistance exercise. Findings showed that Rg1 supplementation further reduced cellular aging markers and inflammatory indicators in skeletal muscle beyond the effects of exercise alone.

Aerobic exercise raises the p16INK4a marker in muscle progenitor cells

Post URL
This human study examined how skeletal muscle cells respond to aerobic exercise at the genetic level, and how Senactiv® ginsenoside Rg1 influences that response. Findings showed that Rg1 accelerated the resolution of exercise-induced cellular stress markers in skeletal muscle, suggesting a role in supporting the muscle's natural recovery process following exercise.

Ginsenoside Rg1 supports muscle stem (satellite) cells lost during exercise

Post URL
This randomized, double-blind human study examined how Senactiv® ginsenoside Rg1 influences muscle satellite cells — the cells responsible for muscle repair and regeneration — following exercise. Findings showed that Rg1 supplementation restored satellite cell numbers and supported muscle recovery markers in the hours following exercise.

Ginsenoside Rg1 clears a cellular aging marker in exercising human muscle

Post URL
This randomized, double-blind human study examined how Senactiv® ginsenoside Rg1 influences cellular senescence markers in skeletal muscle during exercise. Findings showed that Rg1 supplementation effectively cleared senescent cells in exercised muscle during recovery, alongside improvements in high-intensity endurance performance.

How astragaloside II supports gut lining renewal through L-arginine uptake and mTOR

Post URL
This in vitro and in vivo study examined how Astragaloside II, a key compound in AstraGin®, influences intestinal wall integrity. Findings showed enhanced L-arginine absorption through key transport proteins and activation of cellular growth signaling pathways.

Astragaloside IV helps limit collagen loss via TGF-β/Smad and MMP-1

Post URL
This in vitro study examined how Astragaloside IV, a key compound in Astrion®, influences collagen levels in human skin cells following induced damage. Findings showed it supported collagen synthesis by modulating key signaling pathways and reducing the activity of MMP-1, an enzyme involved in collagen breakdown.

Ginsenoside Rg1 improves inflammatory balance in exercising human muscle

Post URL
This randomized, double-blind human study examined how Senactiv® ginsenoside Rg1 influences muscle recovery and exercise performance. Findings showed improved post-exercise glycogen replenishment, reduced oxidative stress markers, a more favorable inflammatory balance in skeletal muscle, and a ~20% increase in cycling time to exhaustion.

How the protein CREB drives Rg1's effect on the SGLT1 glucose transporter gene

Post URL
This in vitro and in vivo study examined how InnoSlim® ginsenoside Rg1 reduces glucose absorption in intestinal cells, identifying the specific cellular signaling pathway responsible for lowering the activity of SGLT1 — a key nutrient transport protein in the intestinal wall.

Ginsenoside Rg1 lowers glucose and lipid production in human liver cells

Post URL
This in vitro study examined how InnoSlim® ginsenoside Rg1 influences glucose and lipid metabolism in human liver cells. Findings showed that Rg1 modulated glucose production and lipid synthesis through activation of key metabolic signaling pathways.

Astragalus reduces the collagen-degrading enzyme MMP-1 in UVB-exposed skin cells

Post URL
This in vitro study examined how Astragalus membranaceus, a key compound in Astrion®, influences collagen synthesis in human skin cells exposed to UVB radiation. Findings showed it supported procollagen synthesis by modulating MMP-1 activity — an enzyme involved in collagen breakdown.

Oral Rg1 strengthens antioxidant defenses against exercise stress in rat muscle

Post URL
This preclinical study examined how Senactiv® ginsenoside Rg1 influences the antioxidant defense system in skeletal muscle under exercise stress. Findings showed that Rg1 supplementation reduced exercise-induced oxidative stress markers and supported antioxidant enzyme activity in muscle tissue.

Ginsenoside Rg1 supports the liver from exhaustive-exercise oxidative stress in rats

Post URL
This preclinical study examined how Senactiv® ginsenoside Rg1 influences liver oxidative stress markers following exhaustive exercise. Findings showed that Rg1 supplementation reduced exercise-induced oxidative damage markers and supported antioxidant enzyme activity in liver tissue.

How ginsenosides CK and Rg1 stimulate glucose uptake in fat cells

Post URL
This preclinical study examined how InnoSlim® ginsenosides CK and Rg1 influence glucose uptake in fat cells. Findings showed that both compounds enhanced glucose uptake by promoting the movement of key glucose transporter proteins to the cell surface through activation of major metabolic signaling pathways.

How ginsenosides change glucose uptake in human gut cells (via the SGLT1 transporter)

Post URL
This in vitro study examined how AstraGin® ginsenosides influence glucose absorption through the intestinal wall, with findings showing that different compounds either enhanced or reduced absorption through modulation of SGLT1 (a key intestinal nutrient transport protein).

Asiaticoside boosts human collagen I through Smad signaling (independent of TRI kinase)

Post URL
This in vitro study examined how asiaticoside, a key compound in Astrion®, influences collagen synthesis in human skin cells. Findings showed it stimulated type I collagen production by activating a specific cellular signaling pathway, providing mechanistic insight into how Astrion® compounds support collagen synthesis at the cellular level.
04
Ready to formulate?

Want the full study references
for a specific ingredient?

Tell us the ingredient. We'll send the complete reference list and put you in front of the team that ran the work.